SpiroChem | Where Chemistry Excellence Accelerates Discovery

Driving innovation in drug discovery and process R&D, offering expert chemistry solutions and seamless support throughout.

Where chemistry excellence accelerates discovery.

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Turning hits
into candidates

SpiroChem is a pioneering research partner driving innovation across the drug discovery and process R&D chemistry value chain. With our world-class dedicated experts working seamlessly as an extension of your team, we offer the ‘best chance of being successful’ significantly derisking your research programs. Thanks to our fully integrated discovery services enabled by our high-quality trusted research partner network, we support your hit-to-candidate journey every step of the way.

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services

We deliver the most robust science and peace of mind

With a diverse portfolio of solutions.

Discovery

Starting from proprietary libraries to comprehensive high-quality medicinal chemistry services, we offer you the ‘best chance of being successful’ in generating a drug candidate.

Process R&D

We pride ourselves in exceptionally high success rates and are committed to delivering the best quality along your chemical process research & development journey.

Fully Integrated Services

With SpiroChem at the center, our integrated discovery services bring together our trusted research partner network supporting you throughout the discovery process with our hit-to-candidate expertise and project management excellence.

Technology

We combine state-of-the-art techniques with deep expertise to deliver solutions that meet the highest standards of quality and efficiency.

Target Validation

Screening

Hit-2-Lead

Lead Optimization

Pre Clinical

Clinical 1,2,3

Market

Tap into our SpiroBrain - offering collective knowledge of the world’s best chemistry minds.

Our strength lies in our people and the collective knowledge they bring to each solution.

SpiroChem’s success is built upon our highly efficient and dynamic team of experts covering various aspects of chemistry and led by seasoned scientific leaders. We pride ourselves in attracting the most talented chemists to join our collaborative and engaging world-class chemistry team.

How we work

Read what our valued clients and collaborators have to say

Testimonials

“Odyssey Therapeutics and SpiroChem collaborated on the synthesis of complex molecules and chemical libraries. The SpiroChem team was highly engaged as we defined the scope and aims of the work. SpiroChem worked quickly to evaluate multiple chemistries in parallel. Together, we defined the most productive and impactful path forward, executing on state-of-the-art, challenging synthetic transformations then quickly converting the results to library production. Our collaboration proceeded smoothly as SpiroChem scientists were model collaborators who communicated promptly, provided very efficient logistics, and exhibited a true can-do spirit. It was a pleasure to work with the SpiroChem team and we look forward to future work together.”

Natalie Dales, Chief of Research Operations and Portfolio Strategy Paul Gormisky, Senior Directory of Chemistry

“SpiroChem has played an instrumental part in Cellestia's drug discovery and development program, proving to be a reliable partner in delivering quality results in a timely manner. Within the framework of this collaboration, the team has spared no effort in meticulously executing the plan and actively participating in project meetings to contribute to the success of our medicinal chemistry efforts. SpiroChem's innovative and effective work helped us save CHF 0,5 million on the drug development program. I thoroughly enjoyed interacting with SpiroChem's team and CEO Dr. Thomas Fessard who always made himself person ally available to discuss the progress of our projects. Without any reservations, I would highly recommend SpiroChem to anyone looking for customized, innovative chemistry from a highly-in vested, strinkingly professional team.”

Rajwinder Lehal, Chief Scientific Officer

“We greatly appreciated our collaboration with SpiroChem, whose partnership allowed us to efficiently tackle complex synthetic challenges across our research programs. Their team combines deep expertise in cutting-edge synthetic and medicinal chemistry with a pragmatic approach to speed, quality, and problem solving. Beyond their direct scientific contributions, SpiroChem played a key coordinating role across our extended network of external CRO partners in China, India, and Ukraine. Their proactive management, technical oversight, and troubleshooting support have been instrumental in maintaining consistency, accelerating timelines, and ensuring scientific rigor throughout our global chemistry operations.”

Chris Oalmann, Vice President Medicinal Chemistry

“We highly value our collaboration with Spirochem, which enables us to address complex synthetic challenges across our pipeline programs. Their team demonstrates deep expertise in contemporary synthetic methodologies, and maintains rigorous attention to detail while aligning with our priorities for speed and efficiency. They additionally provide critical support to the Remix team by troubleshooting CRO-executed chemistry in China, contributing technical insight and actionable guidance through attendance at joint working group meetings.”

Benoit Moreau, Head of Medicinal Chemistry

“The SpiroChem team is an outstanding partner for NBE-Therapeutics for finding and optimizing complex synthesis routes for our linker-payloads. SpiroChem’s Team member’s ingenuity, efficiency and proactive attitude was key in finding novel avenues for synthesizing highly complex and also highly cytotoxic small molecules. Due to the close interactions between our teams, it feels like SpiroChem’s team is part of NBE.”

Ulf Grawunder COO & CDO of NBE-Therapeutics

"SpiroChem's expertise in synthetic chemistry, combined with their sense of urgency, make them an ideal partner for exploring new chemical space. Our critical collaboration on bicycloalkyl bioisosteres was published on ChemMedChem 2017 12 590. I have to highlight the ease of communication and the proactive role of SpiroChem, which we regularly experienced in our interactions. They are brilliant to work with, bother for standard synthesis or more demanding customized building blocks and I would recommend their services to any company seeking pragmatic, cutting-edge solutions."

Dr. Yves P. Auberson, executive director, Global Discovery Chemistry, Novartis Institutes for BioMedical Research and president of EEMC.

"It is with great joy that I am recommending SpiroChem based on the excellent job they did for us; Their high flexibility and reactivity to our fast-changing requests were outstanding. Furthermore, SpiroChem's excellent synthetic expertise enabled access to a key API, which we tested and proved to be the basis for the IP of a complete class of substances. Last but not least, I want to emphasize the outstanding and the fast delivery of the very detailed and precise final report with all the analytical documentation included.”

Dr. Peter C. Sennhenn, CEO of transMedChem Consulting

“We partnered with SpiroChem as part of a pilot structure-based drug design and medicinal chemistry campaign. The outcome was very successful! Despite time, budget and even technical constraints, the SpiroChem team promptly addressed our difficulties providing innovative and unexplored chemical solutions. We were able to design improved compounds, better understand the chemical biology of our project, and lay the foundation for further development campaigns. The SpiroChem Chemistry team has closely supported us through the entire process providing ideas and detailed clarification of the strategies undertaken. A great partnership that I am sure to be continued!”