Macrocycles are powerful tools in drug discovery, They combine the target reach of biologics with the cell permeability of small molecules, making them particularly effective for difficult-to-drug targets where linear compounds often fall short.
Thanks to their large surface area and constrained, pre-organized 3D-rich scaffolds, macrocycles can:
- Expand accessible chemical space beyond traditional small molecules
- Enable novel binding modes
- Effectively target large, flat, or shallow protein surfaces (e.g., PPIs, transcription factors, scaffolding proteins)
At SpiroChem, we bring deep expertise in the design and synthesis of innovative small-molecule-like macrocycles, tailored to your specific discovery needs.
Whether you're starting from a hit, a concept, or exploring new modalities, our team is ready to support your next step.
Contact us to explore case studies and discuss your project.
