In the early stages of discovery and development, selecting the right synthetic route is a key factor in project success. Investing in non-viable pathways can lead to significant delays and unnecessary costs.
At SpiroChem, we address this challenge through an integrated Route Scouting approach. By leveraging High-Throughput Experimentation (HTE), we are able to evaluate multiple reaction pathways, conditions, and strategies in parallel. This experimental data is combined with retrosynthetic analysis and early cost-of-goods assessment to generate a focused shortlist of viable and scalable synthetic routes.
Analyze-Brainstorm-Propose
- •Critically analyze available data
- •Brainstorm and generate alternatives, from complete de novo synthesis to smart tuning or orchestrating of existing sequences
Experimental Route Scouting
- •Test, challenge and rank ideas on sub-gram scale (fail-fast approach leveraging our HTE platform)
- •Critically assess the viable routes and select the most promising one
- •Perform scale-up to evaluate scalability
Development / Optimization
- •Screen alternative reaction conditions (HTE Platform)
- •Telescop steps
- •Implement purification strategies
- •Check impurity profile
- •Develop meaningful in-process controls
- •Test reproducibility
Importantly, successful scale-up requires more than simply increasing batch size. It involves anticipating industrial constraints from the outset, including heat and mass transfer, mixing efficiency, impurity formation, and downstream processing challenges such as crystallization.
By incorporating these considerations early in development, SpiroChem enables its partners to reduce risk, streamline decision-making, and advance only robust and scalable synthetic strategies.
If you would like to learn more about our approach, our experts would be pleased to discuss your project needs. Feel free to get in touch.
