The SpiroQuest™ library, developed by SpiroChem, offers a unique collection of macrocyclic compounds engineered to maximize impact in modern drug discovery.
Strategically positioned between small molecules and highly complex macrocycles, SpiroQuest™ compounds combine structural sophistication with drug-like properties.
Key features of the library:
- Molecular weight typically ranging from 500 to 1000 Da
- Built from 4 to 7 modular building blocks, including canonical and non-canonical α-amino acids, β-amino acids, and non-peptidic linkers
- Fine-tuned control over lipophilicity, permeability, solubility, and flexibility—critical parameters for oral bioavailability
Why it matters:
SpiroQuest™ enables efficient targeting of extended or shallow binding epitopes, often inaccessible to traditional small molecules. At the same time, compounds remain sufficiently compact to support:
- Rapid hit-to-lead progression
- Efficient lead optimization
- Immediate application of advanced peptidomimetic strategies
Whether you're initiating a screening campaign or advancing a promising hit, SpiroQuest™ provides a powerful starting point.
Contact us to learn more or explore relevant case studies.
